Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma

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Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma

Purpose To identify genomic mutations in lacrimal gland adenoid cystic carcinoma (LGACC) samples from patients. Methods Genomic DNA was extracted from LGACC specimens. Whole exome sequencing (exome-seq) was conducted to screen for mutations. Capillary sequencing was performed to verify mutations in genes shared by multiple samples. Luciferase assays were used to evaluate functional consequenc...

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Adenoid cystic carcinoma of the lacrimal gland is a relatively rare disease. Only two cases, a man of 61 and a woman of 54 were seen in our clinic from 1962-1981. They presented histopathology of the cribriform pattern characteristic of adenoid cystic carcinoma. The lesion in the male patient belonged to the solid type and was mainly composed of solid nests. It is emphasized that radiotherapy i...

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Correction: Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma.

Adenoid cystic carcinomas (ACC) of the salivary glands are challenging to understand, treat, and cure. To better understand the genetic alterations underlying the pathogenesis of these tumors, we performed comprehensive genome analyses of 25 fresh-frozen tumors, including whole-genome sequencing and expression and pathway analyses. In addition to the well-described MYB-NFIB fusion that was foun...

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Metachronous Bilateral Adenoid Cystic Carcinoma of the Lacrimal Gland

1 Turkish Ministry of Health Ankara Atatürk Training and Research Hospital, Ankara Turkey 2 Turkish Ministry of Health Kayseri Education and Research Hospital, Kayseri, Turkey. 3 Başkent University Ankara Hospital, Ankara Turkey 4 Turkish Ministry of Health Dr.A.Y. Ankara Oncology Training and Research Hospital. Ankara Turkey 5 Retired Radiation Oncologist. Ankara Turkey Case Report American Jo...

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Adenoid cystic carcinoma of the Bartholin's gland has been encountered in 11 patients at the University of Michigan Medical Center since 1936. At the time of presentation the average age was 48.9 years, the lesion size was between 0.5 to 4 cm. The presenting symptoms were pain and/or pruritis associated with a solitary mass. Early in this series, excisional biopsy was used to treat eight patien...

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ژورنال

عنوان ژورنال: Investigative Opthalmology & Visual Science

سال: 2017

ISSN: 1552-5783

DOI: 10.1167/iovs.16-21097